Undefeated boxing superstar Money, who fought at the famous casino venue for the final dozen bouts of his career, has come out of retirement to face UFC lightweight champion McGregor.
The Irishman has struck a deal with UFC president Dana White to allow him to compete in the one-off event.
Talks between Mayweather’s adviser Al Haymon and the UFC are ongoing but the American has been pictured sparring , suggesting his preparations are well underway.
His promotional company have also reserved the arena on August 25 for a weigh-in.
The as yet unannounced fights the following evening will be shown on Showtime, Mayweather’s long-time broadcaster of choice.
Fighters from the Las Vegas resident’s stable are expected to feature on the undercard, including Badou Jack, who could face WBA world light-heavyweight champion Nathan Cleverly.
McGregor, who has not fought since he won the UFC lightweight title last November, recently became a father for the first time.
He has never boxed professionally having switched to mixed martial arts as a youngster.