The Argentina international was booed from the outset by the home support at Old Trafford, and nearly had to leave the field with a first-half injury after United captain Ashley Young shoved him into the pitchside fence.
Di Maria would have the last laugh, with PSG comfortably beating the hosts thanks to goals by Presnel Kimpembe and the irrepressible Kylian Mbappe.
The versatile midfielder joked by pretending to drink from the bottle before handing it to an official, but should the incident be included in the match referee’s report then European football’s governing body could well take action against the Manchester club.
Di Maria endured a tough season at United after becoming a £60m signing and inheriting the club’s famous number 7 shirt that had been worn by legends George Best, Eric Cantona and Cristiano Ronaldo.
In many ways the diminutive playmaker became a casualty of Louis van Gaal’s dysfunctional regime, and that miserable season under the Dutchman resulted in Di Maria’s only season in the last decade without a single trophy.
Paris Saint-Germain came in for him at the end of that disappointing campaign and Di Maria was only too happy to swap the north-west for Ligue 1 and a fresh start in Paris, where he has since rediscovered his form and proven his worth as a top-class midfielder.
But resentment still lingers with the Old Trafford crowd making their feelings clear and Di Maria returning the favour, shouting a very English expletive back at the home supporters when PSG went ahead through Kimpembe’s header.